|
KMID : 0882420150880030281
|
|
Korean Journal of Medicine
2015 Volume.88 No. 3 p.281 ~ p.287
|
|
|
Drug-Induced Anaphylaxis in a Single Korean Tertiary Hospital
|
|
Moon Il-Joo
Park Hye-Jung
Kim Sung-Ryeol
Koh Beom-Seok
Leem Dong-Woo
Park Kyung-Hee
Lee Jae-Hyun
Park Jung-Won
|
|
|
Abstract
|
|
|
Background/Aims: Drug-induced anaphylaxis (DIA) is a severe, acute, and potentially life-threatening condition. In Korea, only a few well-documented cases of DIA have been described. Therefore, the aim of this study was to investigate the clinical characteristics, causes, and management of DIA in a single Korean medical institute.
Methods: This was a retrospective medical record review of all DIA patients who visited the in-patient, out-patient, and emergency departments of our hospital from January 1 2006 to October 30 2013.
Results: Among 605 cases of anaphylaxis, 167 were drug-induced. The culprit drugs were contrast agents (43 cases, 25.7%), antibiotics (38, 22.8%), non-steroidal anti-inflammatory drugs (35, 21.0%), anti-cancer drugs (22, 13.2%), parenteral vitamins (9, 5.4%), ranitidine (6, 3.6%), and neuromuscular blockers (3, 1.8%). The most common organ-specific symptoms/signs were cardiovascular (74.3%), cutaneous (71.3%), respiratory (55.7%), and gastrointestinal manifestations (19.2%). In most cases, DIA was treated with antihistamines (77.2%) and systemic corticosteroids (76.5%); the use of epinephrine was considerably less frequent (35.3%).
Conclusions: In our institution, contrast agents were the leading cause of DIA. Although epinephrine is the drug of choice in the treatment of acute anaphylaxis, fewer than 50% of the study patients received epinephrine to treat DIA.
|
|
|
KEYWORD
|
|
|
Anaphylaxis, Epidemiology, Epinephrine, Adverse drug reaction
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|
|